Combining metabolome and clinical indicators with machine learning provides some promising diagnostic markers to precisely detect smear-positive/negative pulmonary tuberculosis대사체와 임상 지표를 기계 학습과 결합하면 도말 양성/음성 폐결핵을 정확하게 감지하는 몇 가지 유망한 진단 마커를 제공합니다.Article Published on 2022-08-252022-09-11 Journal: BMC Infectious Diseases [Category] Coronavirus, 바이오마커, 치료기술, [키워드] Amino acid Analysis best Biomarker Biomarkers cause Characteristics Combination conducted Control controls COVID-19 death death case death cases detect Diagnosis diagnostic diagnostic biomarker Diagnostic biomarkers discriminant analysis dysfunction enriched pathways fatty Fatty acid feature global pandemic high accuracy Infectious disease machine machine learning marker metabolisms metabolite metabolome metabolomic metabolomic analysis metabolomic profiling metabolomics Mycobacterium tuberculosis Mycobacterium tuberculosis (Mtb) offer Patient patients performed plasma Precision provide pulmonary tuberculosis R package random Random forest Seven significant enrichment smear Smear-positive/negative pulmonary tuberculosis Support SVM TB patient three group three groups Tuberculosis Tuberculosis (TB). was performed [DOI] 10.1186/s12879-022-07694-8 PMC 바로가기 [Article Type] Article
Congenital Infection of Severe Acute Respiratory Syndrome Coronavirus 2 With Intrauterine Fetal Death: A Clinicopathological Study With Molecular Analysis자궁 내 태아 사망을 동반한 중증 급성 호흡기 증후군 코로나바이러스 2의 선천적 감염: 분자 분석을 통한 임상병리학적 연구Case Reports Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Analysis best Chain Reaction congenital congenital infection consequence coronavirus coronavirus 2 death demise described Diagnosis explained fetal fetal death fetal growth retardation fetus gestation growth growth retardation hemosiderosis hepatocellular histological Immunochemistry in utero in utero x death independent Infection knowledge lesions liver maternal-fetal transmission Mild miscarriage miscarriage. molecular mother Necrosis Neonatal observation observations occurred placental polymerase chain polymerase chain reaction polymerase chain reaction) Quantitative quantitative polymerase chain reaction respiratory SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection secondary to severe acute respiratory syndrome Coronavirus specimen symptomatic SARS-CoV-2 infection the SARS-CoV-2 genome tissue damage tissues Transmission variant vertical transmission virus visceral [DOI] 10.1093/cid/ciab840 PMC 바로가기 [Article Type] Case Reports
Clinical Performance of a Standardized Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Interferon-γ Release Assay for Simple Detection of T-Cell Responses After Infection or Vaccination감염 또는 백신 접종 후 T-세포 반응의 간단한 검출을 위한 표준화된 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 인터페론-γ 방출 분석의 임상 성능Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, 치료기술, [키워드] 19 2 95% confidence interval Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 best Cell cell response Chain Reaction clinical convalescent Convalescent patients coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 CoV COVID COVID-19 dependent on detection disease severity Euroimmun evaluated Follow-up Germany healthy IFN-γ IFN-γ response IFN-γ responses IGRA immune response individual Infection interferon interferon-γ magnitude Mild disease mild infections Neutralizing antibodies neutralizing antibody Patient performance polymerase chain reaction positive Primary infection Prospective Study Quantitative reference standard Release respiratory response reverse transcription Reverse transcription-polymerase chain reaction SARS SARS-CoV-2 SARS-COV-2 infection sensitivity serological serological test Serological tests serology severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severity severity of illness simple specificity subject subjects T T-cell T-cell Response uninfected vaccination was measured Whole blood with mild disease γ release assay. [DOI] 10.1093/cid/ciab1021 PMC 바로가기 [Article Type] Article
Anti-SARS-CoV-2 seroprevalence in King County, WA-Cross-sectional survey, August 2020킹 카운티, WA-단면 조사, 2020년 8월의 Anti-SARS-CoV-2 혈청 유병률Article Published on 2022-08-222022-09-11 Journal: PLoS ONE [Category] SARS, 진단, 치료법, [키워드] 95% confidence interval Accuracy age all age groups anti-SARS-CoV-2 antibody best cause children conducted COVID-19 cross-sectional dried blood spot Dried blood spots effective sample size Factor FIVE highest Hispanic Hospitalization Household survey Households Immunoglobulin Immunoglobulin G incidence income Infection King lowest Older participant Positive test Prevalence proportion Protein provided random SARS-CoV-2 Seroprevalence seroprevalence survey Seven Sex Spike protein statistically significant tested the spike protein the viral nucleocapsid Viral viral nucleocapsid protein virus Weighting white [DOI] 10.1371/journal.pone.0272783 PMC 바로가기 [Article Type] Article
The Clinical Efficacy and Safety of Anti-Viral Agents for Non-Hospitalized Patients with COVID-19: A Systematic Review and Network Meta-Analysis of Randomized Controlled TrialsCOVID-19를 가진 비 병원 환자에 대한 항 바이러스 제제의 임상 효능 및 안전성 : 무작위 대조 시험의 체계적인 검토 및 네트워크 메타 분석Review Published on 2022-08-022022-08-31 Journal: Viruses [Category] meta-analysis, 임상, 치료제, [키워드] adverse event adverse events agent anti-viral agent anti-viral agents Anti-viral treatment best calculated clinical Clinical efficacy clinical setting Cochrane Library Controlled controlled trials COVID-19 death determined by Disease progression followed by Hospitalization increased risk Intravenous remdesivir investigated lowest molnupiravir network Network meta-analysis Nirmatrelvir nirmatrelvir plus ritonavir Patient patients with COVID-19 Placebo Probability Randomized controlled trial RCT RCTs receiving registry Remdesivir remdesivir. review risk risk of COVID-19 Ritonavir Safety searched shown significantly lower the WHO tolerable Treatment Web of Science WHO International Clinical Trials Registry Platform [DOI] 10.3390/v14081706 PMC 바로가기 [Article Type] Review
Evaluation of hematological parameters and inflammatory markers in children with COVID-19COVID-19 소아의 혈액학적 매개변수 및 염증 표지자 평가Article Published on 2022-08-012022-09-11 Journal: Irish Journal of Medical Science [Category] 바이오마커, [키워드] 95% CI abnormality applied best blood cell C-reactive protein C-reactive protein (CRP can be used children children with COVID-19 COVID-19 CRP cutoff value D-dimer determine distribution Effect evaluate hematological hematological parameter hematological parameters hemoglobin Hospitalization identify independent predictor independent predictors Inflammatory biomarker inflammatory biomarkers Inflammatory marker inflammatory markers Inflammatory markers. Inpatient Inpatients lymphocyte lymphopenia mean platelet volume monocyte multivariate logistic regression neutrophil Outpatient outpatients Patient Platelet platelet counts procalcitonin procalcitonin level Red cell retrospective risk factor Risk factors ROC analysis separated significantly higher significantly lower single-center study study population two groups Volume was performed WBC White blood cell [DOI] 10.1007/s11845-021-02762-5 PMC 바로가기 [Article Type] Article
Thiol level and total oxidant/antioxidant status in patients with COVID-19 infectionCOVID-19 감염 환자의 티올 수치 및 총 산화제/항산화 상태Article Published on 2022-08-012022-09-11 Journal: Irish Journal of Medical Science [Category] 바이오마커, [키워드] antioxidant best blood cell C-reactive protein can be used Care contrary correlated COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients decrease determine disease Evidence ferritin ICU ICU admission ICU patient ICU Patients increase in Infection inflammatory markers intensive care intensive care unit level of care marker neutrophil non-ICU non-ICU patients not need oxidative stress Oxidative stress index parameter Pathogenesis Patient patients with COVID-19 positively correlated predictor procalcitonin recruited ROC Curve serum severity of COVID-19 Stress Support thiol Thiol. two group two groups White blood cell worsening [DOI] 10.1007/s11845-021-02743-8 PMC 바로가기 [Article Type] Article
Repurposing the antibacterial drugs for inhibition of SARS-CoV2-PLpro using molecular docking, MD simulation and binding energy calculation분자 도킹, MD 시뮬레이션 및 결합 에너지 계산을 사용하여 SARS-COV2-PLPRO의 억제를위한 항균제를 재사용Article Published on 2022-08-012022-08-31 Journal: Molecular diversity [Category] SARS, 신약개발, [키워드] acetic acid Amino acid amino acids Antibacterial Antibacterial compounds aromatic rings benzofuran best binding energy cleavage collected complex Compound conserved docked downregulating downregulation drug effective effective inhibitor feature filtered function GRL0617 Host hydrophobic hydrophobic interaction immune system indol inhibitor Interaction interferon interferon-stimulated gene IRF3 ISG15 key amino acid key amino acids MD simulation molecular molecular docking molecular dynamics Molecular dynamics simulation non-structural protein novel corona virus Papain Papain-like protease Papain-like protease (PLpro) PLPro produced promoted protease Protein protein-ligand Proteins removal Replication reported repurposing SARS-CoV SARS-CoV-2 SARS-CoV-2 novel corona virus. SARS-CoV2 similarity stability type I interferon Viral viral growth Zinc ZINC database [DOI] 10.1007/s11030-021-10325-0 PMC 바로가기 [Article Type] Article
Prognostic Value of Mid-Region Proadrenomedullin and In Vitro Interferon Gamma Production for In-Hospital Mortality in Patients with COVID-19 Pneumonia and Respiratory Failure: An Observational Prospective StudyCOVID-19 폐렴 및 호흡부전 환자의 병원 내 사망률에 대한 중간 지역 Proadrenomedullin 및 체외 인터페론 감마 생산의 예후적 가치: 관찰적 전향적 연구Observational Study Published on 2022-07-302022-09-11 Journal: Viruses [Category] MERS, 바이오마커, 임상, [키워드] 95%CI Admission Adult patients adverse outcome adverse outcomes AUROC best Biomarker cause characterized Coagulopathy Comorbidity coronavirus coronavirus disease COVID-19 COVID-19 pneumonia COVID-19 vaccination cut-off cut-off point Deceased dysregulation endothelial damage enrolled Enrollment Evidence evidence of females Gamma groups Hospital mortality Hospitalization IFNγ immune dysregulation Immune suppression Immunocompromised patients in vitro in-hospital mortality infection risk interferon interferon gamma median age mid-region proadrenomedullin MONITOR Mortality MR-proADM Negative predictive value Non-COVID-19 observational study PaO2:FiO2 Patient patients with COVID-19 Pneumonia predict Predictive value predictive value) Production Prognostic factor Prospective quantiferon monitor. radiologic respiratory Respiratory failure SARS-CoV-2 sensitivity significantly specificity subset survivor the median value were measured with COVID-19 with infection [DOI] 10.3390/v14081683 PMC 바로가기 [Article Type] Observational Study
DNA aptamers inhibit SARS-CoV-2 spike-protein binding to hACE2 by an RBD- independent or dependent approachDNA 앱타머는 RBD-독립적 또는 의존적 접근에 의해 hACE2에 대한 SARS-CoV-2 스파이크-단백질 결합을 억제합니다Article Published on 2022-07-182022-09-11 Journal: Theranostics [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] affinity anti-RBD anti-S2 Anti-spike approach aptamer best binding binding affinities binding affinity block can be used Candidates cells conserved coronavirus coronavirus COVID-19 pandemic Delta develop diagnostic DNA DNA aptamer Efficacy ELISA fusion aptamer hACE2 IMPROVE independent Infection inhibit inhibit SARS-CoV-2 inhibitor Interaction Ligand ligands linker molecular New coronavirus omicron optimization outbreak Prevent RBD recognize reported S2-protein SARS-CoV-2 selection process sequence spike-protein spike-protein. the RBD therapeutic variant variants were measured WT spike [DOI] 10.7150/thno.74428 PMC 바로가기 [Article Type] Article